The official webpage for this anti-tamper mechanism says that:
It is said that the people behind it are the same that were behind another anti-tampering (read anti-piracy) technology called StarForce that came out some 10 years ago and holds a record of 424 days without being cracked. Now, so far it seems that this Denuvo technology is pretty strong as it has prevented any of the games protected with it from being cracked/pirated; good for them. Most probably it won't hold forever but that's beside the point of this topic, I'm not suggesting anything of the sort.Denuvo Anti-Tamper technology prevents the debugging, reverse engineering and changing of executable files to strengthen the security of games. It is not a DRM solution, but rather, Denuvo Anti-tamper protects DRM solutions, such as Origin Online Access or the Steam license management system, from being circumvented.
In game modding, executable files rarely need to be debugged, and even rarely patched, for a mod to work. But there are a few instances where understanding key pieces of an executable's inner-workings are the "key" to understanding how some game files are handled, encrypted and/or decrypted, by the game engine. I'm not sure if this problem currently exists with DRM solution or not.
The Wikipedia page for this technology, although unofficial and possibly unreliable, says the following:
I assume that the success of this technology may tell us that more games will use it in the future and I'm curious to know what the experts in this forum think of it, if they have a more technical insight about this new technology, what makes it so effective, and how it may affect or hinder attempts at game modding; particularly when so many companies don't support modding at all.[it is] suggested that Denuvo Anti-Tamper employs a "64-bit encryption machine" that requires cryptographic keys unique to the specific hardware of the installed system.